Perlstein Lab

Leave no mutation behind

PLab is the first Public Benefit Corporation accelerating precision drug discovery for 5,000+ rare genetic diseases.

  • 1 in 12 people has an orphan disease. 95% of orphan diseases have no treatment.

  • Each disease is caused
    by a spectrum of genetic mutations.

  • Perlstein Lab studies each mutation
    in model organisms to produce precision medicine.


New insights into targets for Niemann Pick C therapies through Drosophila genetics

Here I’ll sum up a recent paper in Developmental Cell by E. Thomas Danielson and Morten E. Moeller.  The paper, entitled “A Drosophila Genome-Wide Screen Identifies Regulators of Steroid Hormone Production and Developmental Timing,” utilized the Vienna Drosophila RNAi Center’s RNAi collection.  This is a set of thousands of fly strains, where each enables the expression of […]