Perlstein Lab

Leave no mutation behind

PLab is the first Public Benefit Corporation accelerating precision drug discovery for 5,000+ rare genetic diseases.

  • 1 in 12 people has an orphan disease. 95% of orphan diseases have no treatment.

  • Each disease is caused
    by a spectrum of genetic mutations.

  • Perlstein Lab studies each mutation
    in model organisms to produce precision medicine.


A yeast model of cystic fibrosis

At PLab we’re always on the lookout for new publications describing simple animal models of rare genetic diseases. The more non-obvious the model/disease fit appears at first blush, the more exciting are any results that confirm therapeutic relevance in humans — or more accurately in human cells. Last week, a UK-based cystic fibrosis (CF) patient and rare disease advocate […]